Description
GATA4 (Phospho-Ser105)Transcription Factor Activity Assay
The GATA4 Phospho-Ser105 Transcription Factor Activity Assay is a highly sensitive and specific kit designed for the accurate detection of GATA4 activity in various biological samples. GATA4 is a transcription factor that plays a crucial role in regulating gene expression involved in cardiac development and function.This assay allows researchers to measure the phosphorylation of GATA4 at serine 105, providing valuable insights into the activity of this transcription factor.
With its reliable and reproducible results, this assay is ideal for studying the role of GATA4 in various physiological and pathological conditions, including cardiovascular diseases and cardiac development.Overall, the GATA4 Phospho-Ser105 Transcription Factor Activity Assay is a valuable tool for researchers looking to study the regulatory mechanisms of GATA4 and its potential implications in disease pathology and therapeutic development.
| Product Name: | GATA4 (Phospho-Ser105)Transcription Factor Activity Assay |
| Product Code: | TFAB00032 |
| Target: | GATA4 (Phospho-Ser105) |
| Synonyms: | GATA-binding factor 4 |
| Reactivity: | Human, Mouse |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie GATA4 (Phospho-Ser105) transcription factor activity assay allows for the detection and qualitative analysis of GATA4 (Phospho-Ser105) active transcription factors in eukaryotic nuclear or cell lysates.
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | GATA4: a conserved and ubiquitous member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. May regulate a set of cardiac-specific genes and play a crucial role in cardiogenesis. Defects are a cause of atrial septal defect 2 (ASD2). ASD2 is an autosomal dominant condition with atrial septal defect and other congenital heart disease but no conduction defects or noncardiac abnormalities. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Transcription factor Chromosomal Location of Human Ortholog: 8p23.1-p22 Cellular Component: nucleoplasm; nucleus Molecular Function:chromatin binding; DNA binding; protein binding; sequence-specific DNA binding; transcription activator binding; transcription coactivator activity; transcription factor activity; transcription factor binding Biological Process: anatomical structure formation; blood coagulation; cell development; cell fate commitment; cell-cell signaling; embryonic foregut morphogenesis; embryonic heart tube anterior/posterior pattern formation; endoderm development; heart looping; male gonad development; positive regulation of angiogenesis; positive regulation of cardioblast differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; response to drug; transcription from RNA polymerase II promoter Disease: Atrial Septal Defect 2; Atrioventricular Septal Defect 4; Testicular Anomalies With Or Without Congenital Heart Disease; Tetralogy Of Fallot; Ventricular Septal Defect 1 |
| NCBI Summary: | This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function, and is necessary for normal testicular development. Mutations in this gene have been associated with cardiac septal defects. Additionally, alterations in gene expression have been associated with several cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] |
| UniProt Code: | P43694 |
| NCBI GenInfo Identifier: | 215274105 |
| NCBI Gene ID: | 2626 |
| NCBI Accession: | P43694.2 |
| UniProt Secondary Accession: | P43694,Q3MJ45, Q5IFM8, B7ZKX0, B7ZKZ4, |
| UniProt Related Accession: | P43694 |
| Molecular Weight: | 44,665 Da |
| NCBI Full Name: | Transcription factor GATA-4 |
| NCBI Synonym Full Names: | GATA binding protein 4 |
| NCBI Official Symbol: | GATA4 |
| NCBI Official Synonym Symbols: | TOF; ASD2; VSD1; TACHD |
| NCBI Protein Information: | transcription factor GATA-4 |
| UniProt Protein Name: | Transcription factor GATA-4 |
| UniProt Synonym Protein Names: | GATA-binding factor 4 |
| Protein Family: | GATA transcription factor |
| UniProt Gene Name: | GATA4 |
| UniProt Entry Name: | GATA4_HUMAN |
