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Anti-GBP1 Antibody (CAB6911)

SKU:
CAB6911
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
  • Immunology Antibodies 2 Anti-GBP1 Antibody CAB6911
  • Immunology Antibodies 2 Anti-GBP1 Antibody CAB6911
€139 - €419
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Description

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Antibody Name:Anti-GBP1 Antibody
Antibody SKU:CAB6911
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 383-592 of human GBP1 (NP_002044.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human
Positive Samples:5637(HTB-9)
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 383-592 of human GBP1 (NP_002044.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ELAA QLEK KRDD FCKQ NQEA SSDR CSAL LQVI FSPL EEEV KAGI YSKP GGYR LFVQ KLQD LKKK YYEE PRKG IQAE EILQ TYLK SKES MTDA ILQT DQTL TEKE KEIE VERV KAES AQAS AKML QEMQ RKNE QMME QKER SYQE HLKQ LTEK MEND RVQL LKEQ ERTL ALKL QEQE QLLK EGFQ KESR IMKN EIQD LQTK MRRR KACT IS
Gene ID:2633
Uniprot:P32455
Cellular Location:Cell membrane, Cytoplasm, Cytoplasmic side, Golgi apparatus membrane, Lipid-anchor, Secreted
Calculated MW:67kDa
Observed MW:68kDa
Synonyms:GBP1
Background:Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3.
UniProt Protein Function:GBP1: a member of the family of large GTP-binding proteins (GBPs) that is inducible by interferon. Possesses a high GTP hydrolysis activity. GBPs are the most abundant cellular proteins expressed in response to interferon-gamma (IFN-gamma). IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) strongly induce the expression of GBP-1, -2, and -3.
UniProt Protein Details:

Protein type:Hydrolase; Cell adhesion; Vesicle

Chromosomal Location of Human Ortholog: 1p22.2

Cellular Component: cytosol; extracellular region; Golgi membrane; plasma membrane

Molecular Function:actin binding; cytokine binding; enzyme binding; GTP binding; GTPase activity; Hsp90 protein binding; identical protein binding; protein binding; spectrin binding

Biological Process: cytokine and chemokine mediated signaling pathway; defense response to virus; metabolic process; negative regulation of T cell receptor signaling pathway; regulation of calcium-mediated signaling

NCBI Summary:Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008]
UniProt Code:P32455
NCBI GenInfo Identifier:311033383
NCBI Gene ID:2633
NCBI Accession:P32455.2
UniProt Secondary Accession:P32455,Q5T8M1, D3DT26,
UniProt Related Accession:P32455
Molecular Weight:
NCBI Full Name:Guanylate-binding protein 1
NCBI Synonym Full Names:guanylate binding protein 1
NCBI Official Symbol:GBP1  
NCBI Protein Information:guanylate-binding protein 1
UniProt Protein Name:Guanylate-binding protein 1
UniProt Synonym Protein Names:GTP-binding protein 1; GBP-1; HuGBP-1; Guanine nucleotide-binding protein 1; Interferon-induced guanylate-binding protein 1
Protein Family:Guanylate-binding protein
UniProt Gene Name:GBP1  
UniProt Entry Name:GBP1_HUMAN
Anti-GBP1 Antibody (CAB6911)Western blot analysis of extracts of 5637(HTB-9) cells, using GBP1 antibody (CAB6911) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
Anti-GBP1 Antibody (CAB6911)Immunofluorescence analysis of U2OS cells using GBP1 antibody (CAB6911). Blue: DAPI for nuclear staining.

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