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GenieFluor Red 780 Anti-Mouse CD8a Antibody [53-6.7] (AGEL2973)

Datasheet MSDS
SKU AGEL2973
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Mouse
Host Species Rat
Isotype Rat IgG2a, κ
Clone 53-6.7
Conjugation AFRed 780
$53 - $143

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Description

system_update_altDatasheetsystem_update_altMSDS

GenieFluor Red 780 Anti-Mouse CD8a Antibody [53-6.7]

The GenieFluor™ Red 780 Anti-Mouse CD8a Antibody (53-6.7) (AGEL2973) is a highly specific and sensitive tool for researchers studying mouse CD8a, a key cell surface marker on cytotoxic T cells. This monoclonal antibody, raised in mice, is optimized for use in flow cytometry and immunofluorescence applications, allowing for precise identification and characterization of CD8a-positive cells in various biological samples.CD8a is a crucial marker on cytotoxic T cells that plays a vital role in immune response by recognizing and eliminating infected or abnormal cells. The ability to accurately detect and quantify CD8a expression is essential for studying immune cell populations, immune responses, and immunotherapy efficacy.

This antibody's reliable performance and specificity make it an indispensable tool for immunologists, oncologists, and researchers investigating immune cell function and dynamics in health and disease.By using the GenieFluor™ Red 780 Anti-Mouse CD8a Antibody (53-6.7) (AGEL2973), researchers can delve deeper into the intricate mechanisms of immune surveillance, antigen recognition, and immune cell interactions. This antibody's high affinity and sensitivity make it an invaluable resource for advancing our understanding of immune systems and developing novel therapeutic strategies targeting CD8a-positive immune cells.

Product Title:GenieFluor Red 780 Anti-Mouse CD8a Antibody [53-6.7]
SKU:AGEL2973
Size:50 Tests, 100 Tests, 200 Tests
Clone No:53-6.7
Synonyms:T-cell surface glycoprotein CD8 alpha chain;CD8A;T-lymphocyte differentiation antigen T8/Leu-2;MAL;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:Genie Fluor Red 780 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:Genie FluorRed 780
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P01731
Gene ID:12525
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α(CD8a)/β(CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.
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