Description

GenieFluor Violet 450 Anti-Mouse CD8a Antibody [53-6.7]

The GenieFluor Violet 450 Anti-Mouse CD8a Antibody (53-6.7) is a potent tool for researchers studying immune responses and T cell biology in mice. This monoclonal antibody, derived from hybridoma cells, specifically targets CD8a, a cell surface marker found on cytotoxic T cells involved in immune surveillance and response.With high reactivity and specificity for mouse samples, this antibody is a critical component for flow cytometry and immunofluorescence experiments, allowing for precise identification and analysis of CD8a-positive T cells. Its compatibility with various cell types and tissues makes it an invaluable resource for investigating immune cell populations and their roles in immunity, infection, and autoimmunity.

CD8a is a key player in adaptive immune responses, acting as a co-receptor for T cell receptor recognition and activation. Its expression on cytotoxic T cells allows for targeted killing of infected or abnormal cells, making it crucial for immune defense against pathogens and cancer. By targeting CD8a with this antibody, researchers can deepen their understanding of T cell-mediated immune responses and potentially uncover new therapeutic targets for immunomodulation and immunotherapy research.

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Product Title:	GenieFluor Violet 450 Anti-Mouse CD8a Antibody [53-6.7]
SKU:	AGEL2974
Size:	25µg, 100µg
Clone No:	53-6.7
Synonyms:	T-cell surface glycoprotein CD8 alpha chain;CD8A;T-lymphocyte differentiation antigen T8/Leu-2;MAL;
Host Species:	Rat
Reactivity:	Mouse
Application:	FCM

Isotype:	Rat IgG2a, κ
Isotype Control:	Genie Fluor Violet 450 Rat IgG2a, κ Isotype Control[2A3]
Form:	Liquid
Conjugation:	Genie FluorViolet 450
Recommended Use:	Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:

Swissprot:	P01731
Gene ID:	12525
Storage Buffer:	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:	Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:	CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α(CD8a)/β(CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.

GenieFluor Violet 450 Anti-Mouse CD8a Antibody [53-6.7] (AGEL2974)

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Description