Anti-GGCT Antibody (CAB4957)
- SKU:
- CAB4957
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- GGCT
- C7orf24
- CRF21
- GCTG
- GGC
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Product Name: | GGCT Rabbit pAb |
| Product Code: | CAB4957 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | GGCT, C7orf24, CRF21, GCTG, GGC |
| Applications: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-188 of human GGCT (NP_076956.1). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | 293T, A-549, A-431 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-188 of human GGCT (NP_076956.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MANS GCKD VTGP DEES FLYF AYGS NLLT ERIH LRNP SAAF FCVA RLQD FKLD FGNS QGKT SQTW HGGI ATIF QSPG DEVW GVVW KMNK SNLN SLDE QEGV KSGM YVVI EVKV ATQE GKEI TCRS YLMT NYES APPS PQYK KIIC MGAK ENGL PLEY QEKL KAIE PNDY TGKV SEEI EDII KKGE TQTL |
| Gene ID: | 79017 |
| Uniprot: | O75223 |
| Calculated MW: | 10kDa/12kDa/19kDa/21kDa |
| Observed MW: | 21kDa |
| UniProt Protein Function: | GGCT: Catalyzes the formation of 5-oxoproline from gamma- glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis. Belongs to the gamma-glutamylcyclotransferase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 2.3.2.4; Transferase; Apoptosis; Other Amino Acids Metabolism - glutathione Chromosomal Location of Human Ortholog: 7p15-p14 Cellular Component: cytosol Molecular Function:gamma-glutamylcyclotransferase activity; protein homodimerization activity Biological Process: glutathione biosynthetic process; release of cytochrome c from mitochondria |
| NCBI Summary: | The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] |
| UniProt Code: | O75223 |
| NCBI GenInfo Identifier: | 34222503 |
| NCBI Gene ID: | 79017 |
| NCBI Accession: | O75223.1 |
| UniProt Secondary Accession: | O75223,Q9BS37, B2RDN0, B8ZZN4, B8ZZR8, |
| UniProt Related Accession: | O75223 |
| Molecular Weight: | 19,092 Da |
| NCBI Full Name: | Gamma-glutamylcyclotransferase |
| NCBI Synonym Full Names: | gamma-glutamylcyclotransferase |
| NCBI Official Symbol: | GGCTÂ Â |
| NCBI Official Synonym Symbols: | GGC; GCTG; CRF21; C7orf24Â Â |
| NCBI Protein Information: | gamma-glutamylcyclotransferase |
| UniProt Protein Name: | Gamma-glutamylcyclotransferase |
| UniProt Synonym Protein Names: | Cytochrome c-releasing factor 21 |
| Protein Family: | Gamma-glutamylcyclotransferase |
| UniProt Gene Name: | GGCTÂ Â |
| UniProt Entry Name: | GGCT_HUMAN |
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