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Anti-GLUD2 Antibody (CAB6604)

SKU:
CAB6604
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 10 Anti-GLUD2 Antibody CAB6604
  • Cell Biology Antibodies 10 Anti-GLUD2 Antibody CAB6604
  • Cell Biology Antibodies 10 Anti-GLUD2 Antibody CAB6604
  • Cell Biology Antibodies 10 Anti-GLUD2 Antibody CAB6604
  • Cell Biology Antibodies 10 Anti-GLUD2 Antibody CAB6604
  • Cell Biology Antibodies 10 Anti-GLUD2 Antibody CAB6604
€139 - €419
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Description

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Antibody Name:Anti-GLUD2 Antibody
Antibody SKU:CAB6604
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 319-558 of human GLUD2 (NP_036216.2).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:10 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:A-549, MCF7, THP-1, A-431, Mouse brain, Mouse eye, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 319-558 of human GLUD2 (NP_036216.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:YLHR FGAK CIAV GESD GSIW NPDG IDPK ELED FKLQ HGSI LGFP KAKP YEGS ILEV DCDI LIPA ATEK QLTK SNAP RVKA KIIA EGAN GPTT PEAD KIFL ERNI LVIP DLYL NAGG VTVS YFEW LKNL NHVS YGRL TFKY ERDS NYHL LLSV QESL ERKF GKHG GTIP IVPT AEFQ DSIS GASE KDIV HSAL AYTM ERSA RQIM HTAM KYNL GLDL RTAA YVNA IEKV FKVY SEAG VTFT
Gene ID:2747
Uniprot:P49448
Cellular Location:Mitochondrion matrix
Calculated MW:61kDa
Observed MW:55kDa
Synonyms:GLUD2, GDH2, GLUDP1
Background:The protein encoded by this gene is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate. This gene is intronless.
UniProt Protein Function:GLUD2: Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission. Homohexamer. Expressed in retina, testis and, at a lower level, brain. Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
UniProt Protein Details:

Protein type:Amino Acid Metabolism - alanine, aspartate and glutamate; Other Amino Acids Metabolism - D-Glutamine and D-glutamate; Amino Acid Metabolism - arginine and proline; EC 1.4.1.3; Mitochondrial; Oxidoreductase; Energy Metabolism - nitrogen

Chromosomal Location of Human Ortholog: Xq24-q25

Cellular Component: mitochondrion; cytoplasm

Molecular Function:glutamate dehydrogenase activity; glutamate dehydrogenase [NAD(P)+] activity; GTP binding; ADP binding

Biological Process: glutamate catabolic process; glutamate metabolic process; glutamate biosynthetic process

NCBI Summary:The protein encoded by this gene is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate. This gene is intronless.[provided by RefSeq, Jan 2010]
UniProt Code:P49448
NCBI GenInfo Identifier:13432152
NCBI Gene ID:2747
NCBI Accession:P49448.2
UniProt Secondary Accession:P49448,Q9UDQ4, B2R8G0,
UniProt Related Accession:P49448
Molecular Weight:558
NCBI Full Name:Glutamate dehydrogenase 2, mitochondrial
NCBI Synonym Full Names:glutamate dehydrogenase 2
NCBI Official Symbol:GLUD2  
NCBI Official Synonym Symbols:GDH2; GLUDP1  
NCBI Protein Information:glutamate dehydrogenase 2, mitochondrial; GDH 2; glutamate dehydrogenase pseudogene 1
UniProt Protein Name:Glutamate dehydrogenase 2, mitochondrial
UniProt Gene Name:GLUD2  
UniProt Entry Name:DHE4_HUMAN
Anti-GLUD2 Antibody (CAB6604)Western blot analysis of extracts of various cell lines, using GLUD2 antibody (CAB6604) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-GLUD2 Antibody (CAB6604)Immunohistochemistry of paraffin-embedded human liver cancer using GLUD2 antibody (CAB6604) at dilution of 1:100 (40x lens).
Anti-GLUD2 Antibody (CAB6604)Immunohistochemistry of paraffin-embedded human liver damage using GLUD2 antibody (CAB6604) at dilution of 1:100 (40x lens).
Anti-GLUD2 Antibody (CAB6604)Immunohistochemistry of paraffin-embedded human esophageal cancer using GLUD2 antibody (CAB6604) at dilution of 1:100 (40x lens).
Anti-GLUD2 Antibody (CAB6604)Immunohistochemistry of paraffin-embedded human gastric cancer using GLUD2 antibody (CAB6604) at dilution of 1:100 (40x lens).

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