GluN2B Antibody [S59] is a mouse recombinant monoclonal antibody directed against GluN2B, offered by Assay Genie for research applications. Reported applications include WB, IHC, ICC/IF, IP and AM. Reported reactivity: Human, Mouse and Rat. Supplied as IgG2b, purified by Protein G.
NR2B (GRIN2B) is a subunit of the NMDA receptor complex, predominantly expressed during early brain development and in specific regions of the adult brain such as the hippocampus and cortex. NR2B-containing NMDA receptors exhibit slower deactivation kinetics and higher calcium permeability, making them critical for synaptic plasticity, memory formation, and neurodevelopment. In neurodegenerative disease research, NR2B has been implicated in excitotoxicity, a pathological process driven by excessive glutamate signaling and calcium influx. Overactivation of NR2B-containing receptors contributes to neuronal injury in conditions such as Alzheimer’s disease, Parkinson’s disease, and stroke. Pharmacological modulation of NR2B has shown promise in preclinical models for reducing neurotoxicity and improving cognitive function. NR2B-selective antagonists are being explored as therapeutic agents for neuroprotection and symptom management in neurodegenerative and neuropsychiatric disorders. Its developmental regulation and synaptic specificity make NR2B a valuable target for precision neuroscience. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
GluN2B Antibody [S59]
Product SKU:
STMA00098
Size:
100 µg
Target:
GluN2B
Host Species:
Mouse
Antibody Type:
Recombinant Monoclonal
Clone ID:
S59
Research Areas:
Neuroscience, Ion Channels, Neurotransmitter Receptors, Glutamate Receptors, NMDA Receptors, Neurodegeneration
Buffer:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage & Shipping:
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, IHC, ICC/IF, IP, AM
Antibody Isotype:
IgG2b
Purification:
Protein G Purified
Concentration:
1 mg/ml
Reactivity:
Human, Mouse, Rat
Recommended Dilution:
WB (1:1000), IHC (1:100), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Specificity:
Detects ~166kDa. No cross-reactivity against NR2A.
Guarantee:
12 months from date of dispatch
Immunogen:
Fusion protein amino acids 20-271 (extracellular N-terminus) of rat NR2B
