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Anti-GNAO1 Antibody (CAB2510)

SKU:
CAB2510
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
  • Cell Biology Antibodies 8 Anti-GNAO1 Antibody CAB2510
  • Cell Biology Antibodies 8 Anti-GNAO1 Antibody CAB2510
  • Cell Biology Antibodies 8 Anti-GNAO1 Antibody CAB2510
  • Cell Biology Antibodies 8 Anti-GNAO1 Antibody CAB2510
€139 - €419
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Description

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Antibody Name:Anti-GNAO1 Antibody
Antibody SKU:CAB2510
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 60-180 of human GNAO1 (NP_066268.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:Mouse brain, Mouse spinal cord
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 60-180 of human GNAO1 (NP_066268.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GFSG EDVK QYKP VVYS NTIQ SLAA IVRA MDTL GIEY GDKE RKAD AKMV CDVV SRME DTEP FSAE LLSA MMRL WGDS GIQE CFNR SREY QLND SAKY YLDS LDRI GAAD YQPT EQDI LRTR V
Gene ID:2775
Uniprot:P09471
Cellular Location:Cell membrane, Lipid-anchor, Membrane
Calculated MW:40kDa
Observed MW:39kDa
Synonyms:GNAO1, EIEE17, G-ALPHA-o, GNAO, HLA-DQB1, NEDIM
Background:The protein encoded by this gene represents the alpha subunit of the Go heterotrimeric G-protein signal-transducing complex. Defects in this gene are a cause of early-onset epileptic encephalopathy. Two transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:G-alpha(o): Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14. Interacts with RGS14. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Belongs to the G-alpha family. G(i/o/t/z) subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:G protein, heterotrimeric alpha G((i/o/t/z)); G protein; G protein, heterotrimeric

Chromosomal Location of Human Ortholog: 16q13

Cellular Component: neuron projection; plasma membrane; heterotrimeric G-protein complex

Molecular Function:corticotropin-releasing hormone receptor 1 binding; GTPase activity; signal transducer activity; GTP binding; mu-type opioid receptor binding; metal ion binding; G-protein beta/gamma-subunit binding; GTPase activating protein binding; metabotropic serotonin receptor binding

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; response to drug; negative regulation of calcium ion transport; response to hydrogen peroxide; muscle contraction; metabolic process; response to cytokine stimulus; forebrain development; dopamine receptor signaling pathway; response to morphine; locomotory behavior; neurite development; regulation of heart contraction; positive regulation of GTPase activity; aging

Disease: Epileptic Encephalopathy, Early Infantile, 17

NCBI Summary:The protein encoded by this gene represents the alpha subunit of the Go heterotrimeric G-protein signal-transducing complex. Defects in this gene are a cause of early-onset epileptic encephalopathy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
UniProt Code:P09471
NCBI GenInfo Identifier:232133
NCBI Gene ID:2775
NCBI Accession:P09471.4
UniProt Related Accession:P09471
Molecular Weight:
NCBI Full Name:Guanine nucleotide-binding protein G(o) subunit alpha
NCBI Synonym Full Names:G protein subunit alpha o1
NCBI Official Symbol:GNAO1  
NCBI Official Synonym Symbols:GNAO; NEDIM; EIEE17; HLA-DQB1; G-ALPHA-o  
NCBI Protein Information:guanine nucleotide-binding protein G(o) subunit alpha
UniProt Protein Name:Guanine nucleotide-binding protein G(o) subunit alpha
UniProt Gene Name:GNAO1  
UniProt Entry Name:GNAO_HUMAN
Anti-GNAO1 Antibody (CAB2510)Western blot analysis of extracts of various cell lines, using GNAO1 antibody (CAB2510) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Anti-GNAO1 Antibody (CAB2510)Immunohistochemistry of paraffin-embedded human colon carcinoma using GNAO1 Antibody (CAB2510) at dilution of 1:100 (40x lens).
Anti-GNAO1 Antibody (CAB2510)Immunohistochemistry of paraffin-embedded human esophagus using GNAO1 Antibody (CAB2510) at dilution of 1:100 (40x lens).
Anti-GNAO1 Antibody (CAB2510)Immunohistochemistry of paraffin-embedded human esophageal cancer using GNAO1 Antibody (CAB2510) at dilution of 1:100 (40x lens).

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