SFRP2 Antibody is a rabbit polyclonal antibody directed against SFRP2, offered by Assay Genie for research applications. Reported applications include WB and IHC. Reported reactivity: Human and Mouse. Purified by Peptide Affinity.
Secreted frizzled-related protein 2 (SFRP2) is a member of the SFRP family that modulates Wnt signaling—a pathway essential for neurodevelopment, synaptic plasticity, and tissue regeneration. While SFRP2 has been extensively studied in skeletal stem cell biology, emerging evidence suggests its relevance in the central nervous system, particularly in neurodegenerative disease contexts (1). SFRP2 can act as both a Wnt antagonist and agonist, depending on cellular context. In neural tissues, Wnt signaling governs processes such as neuronal differentiation, axonal guidance, and synaptic maintenance. Dysregulation of Wnt pathways has been implicated in Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. SFRP2’s ability to fine-tune Wnt activity positions it as a potential regulator of neuroinflammation and neurogenesis. Recent studies show that SFRP2 deficiency impairs stem cell recruitment and differentiation, suggesting that it may influence neural stem cell function and brain repair mechanisms (1). Its role in modulating LRP6 activation and downstream Wnt target genes such as Axin2 and Cyclin D1 further supports its involvement in maintaining cellular homeostasis under stress or injury. Given its dual regulatory capacity and influence on regenerative signaling, SFRP2 is a promising candidate for therapeutic exploration in neurodegenerative disease. Enhancing SFRP2 activity may promote neural resilience and repair, offering new avenues for intervention in aging and neurodegeneration. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, IHC
Purification:
Peptide Affinity Purified
Concentration:
1 mg/ml
Reactivity:
Human, Mouse
Recommended Dilution:
WB (1:1000); IHC (1:50); optimal dilutions for assays should be determined by the user.
Specificity:
Detects 37 kDa.
Guarantee:
12 months from date of dispatch
Immunogen:
Synthetic peptide from the C-terminal of Human Secreted frizzled-related protein 2 (aa. 195-295)
Immunogen Species:
Human
Accession Number:
NP_003004.1
Gene ID:
6423
Swiss-Prot:
Q96HF1
Cellular Localization:
Secreted
Tissue Specificity:
Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon.
Alternative Names:
SDF5, Secreted frizzled-related protein 2, FRP 2, UNQ361/PRO697, sFRP-2, FKSG12, SFRP2_HUMAN, MGC153618, Frizzled related protein 2, MGC53344, FRP2, FRP-2, SARP1, AI851596, SARP 1, MGC128911, SARP-1, Secreted apoptosis related protein 1, ORF Names:, Secreted apoptosis-related protein 1, SDF 5, Sfrp2 protein, sFRP 2, Secreted frizzled related protein 2
