GRP78 (Bip) Antibody is a rabbit polyclonal antibody directed against GRP78 (Bip), offered by Assay Genie for research applications. Reported applications include WB, IHC, ICC/IF and ELISA. Reported reactivity: Human, Mouse, Rat, Dog, Fruit Fly (Drosophila melanogaster) and Hamster. Purified by Protein A.
GRP78 (also known as BiP) is a 78-kDa glucose-regulated protein and a master regulator of the unfolded protein response (UPR). As a key ER chaperone, it ensures proper protein folding, assembly, and the clearance of misfolded proteins, especially under stress conditions. Its expression is controlled by an internal ribosome entry site (IRES), which becomes highly active during cellular stress, such as heat shock or oxidative damage. GRP78 is essential for maintaining neuronal homeostasis and preventing apoptosis, making it a critical player in neurodegenerative disease contexts. In neuroscience, GRP78 has demonstrated neuroprotective effects against glutamate toxicity and oxidative stress. Its levels are notably reduced in the brains of Alzheimer’s disease patients, highlighting its potential as a biomarker and therapeutic target. Additionally, GRP78 supports embryonic development and pluripotent cell survival, further underscoring its importance in neural cell viability. However, its overexpression under extreme stress may contribute to drug resistance in neuro-oncology, adding complexity to its therapeutic modulation. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
GRP78 (Bip) Antibody
Product SKU:
STPA00029
Size:
100 µg
Target:
GRP78 (Bip)
Host Species:
Rabbit
Antibody Type:
Polyclonal
Research Areas:
Cancer, Heat Shock, Cell Signaling, Protein Trafficking, Chaperone Proteins, Tags and Cell Markers, Organelle Markers
Buffer:
PBS, 50% glycerol, 0.09% sodium azide
Storage & Shipping:
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, IHC, ICC/IF, ELISA
Purification:
Protein A Purified
Concentration:
1 mg/ml
Reactivity:
Human, Mouse, Rat, Dog, Fruit Fly (Drosophila melanogaster), Hamster
Recommended Dilution:
WB (1:2000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Specificity:
Detects ~78kDa.
Guarantee:
12 months from date of dispatch
Immunogen:
Full length human GRP78 (Bip) his tagged at the N terminus
GRP78, GRP-78, Grp78, GRP 78, HSPA5, HSPA 5, Heat shock 70 kDa protein 5, Heat Shock 70kDa Protein 5, BiP, BIP, Binding immunoglobulin protein, Immunoglobulin heavy chain-binding protein, Immunoglobulin Heavy Chain Binding Protein, Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78, Endoplasmic reticulum lumenal, Ca2+ binding protein grp78, Glucose Regulated Protein 78kDa, 78 kDa glucose-regulated protein, 78 kDa glucose regulated protein, HSCe70, MIF2, mBiP, Sez7, AL022860, AU019543, D2Wsu141e, D2Wsu17e, FLJ26106, GRP78_HUMAN
References:
1. Cho S., et al. (2007) Mol Cell Biol. 27(1): 368-83. 2. Yang Y., et al. (1998) J Biol Chem. 273: 25552-25555. 3. Luo S., et al (2006) 26 (15): 5688-97. 4. Yu Z., et al. (1999) Exp Neurol. 15: 302-314. 5. Koomagi R., et al. (1999) Anticancer Res. 19: 4333-4336. 6. Laquerre S., et al. (1998) J. Virology. 72: 4940-4949. 7. Dong D., et al. (2005) Cancer Res. 65(13): 5785-91.
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