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Anti-TIM-3/HAVCR2 Antibody (CAB13443)

SKU:
CAB13443
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
  • Immunology Antibodies 1 Anti-TIM-3/HAVCR2 Antibody CAB13443
  • Immunology Antibodies 1 Anti-TIM-3/HAVCR2 Antibody CAB13443
€139 - €419
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Description

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Antibody Name:Anti-TIM-3/HAVCR2 Antibody
Antibody SKU:CAB13443
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TIM-3/HAVCR2 (NP_116171.3).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:Mouse spleen, Raji
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TIM-3/HAVCR2 (NP_116171.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MFSH LPFD CVLL LLLL LLTR SSEV EYRA EVGQ NAYL PCFY TPAA PGNL VPVC WGKG ACPV FECG NVVL RTDE RDVN YWTS RYWL NGDF RKGD VSLT IENV
Gene ID:84868
Uniprot:Q8TDQ0
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:85kDa/100kDa/105kDa/106kDa
Observed MW:45kDa/70kDa
Synonyms:HAVCR2, CD366, HAVcr-2, KIM-3, TIM3, TIMD-3, TIMD3, Tim-3
Background:The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
UniProt Protein Function:TIM-3: Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9. Belongs to the immunoglobulin superfamily. TIM family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q33.3

Cellular Component: integral to membrane

Disease: Rheumatoid Arthritis

NCBI Summary:The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]
UniProt Code:Q8TDQ0
NCBI GenInfo Identifier:311033536
NCBI Gene ID:84868
NCBI Accession:Q8TDQ0.3
UniProt Related Accession:Q8TDQ0
Molecular Weight:
NCBI Full Name:Hepatitis A virus cellular receptor 2
NCBI Synonym Full Names:hepatitis A virus cellular receptor 2
NCBI Official Symbol:HAVCR2  
NCBI Official Synonym Symbols:TIM3; CD366; KIM-3; SPTCL; TIMD3; Tim-3; TIMD-3; HAVcr-2  
NCBI Protein Information:hepatitis A virus cellular receptor 2
UniProt Protein Name:Hepatitis A virus cellular receptor 2
UniProt Synonym Protein Names:T-cell immunoglobulin and mucin domain-containing protein 3; TIMD-3; T-cell immunoglobulin mucin receptor 3; TIM-3; T-cell membrane protein 3
UniProt Gene Name:HAVCR2  
UniProt Entry Name:HAVR2_HUMAN
Anti-TIM-3/HAVCR2 Antibody (CAB13443)Western blot analysis of extracts of various cell lines, using TIM-3/HAVCR2 antibody (CAB13443) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-TIM-3/HAVCR2 Antibody (CAB13443)Immunofluorescence analysis of Hela cells using TIM-3/HAVCR2 antibody (CAB13443) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

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