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Anti-TIM-3/HAVCR2 Antibody (CAB2516)

SKU:
CAB2516
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology
  • Immunology Antibodies 2 Anti-TIM-3/HAVCR2 Antibody CAB2516
  • Immunology Antibodies 2 Anti-TIM-3/HAVCR2 Antibody CAB2516
  • Immunology Antibodies 2 Anti-TIM-3/HAVCR2 Antibody CAB2516
  • Immunology Antibodies 2 Anti-TIM-3/HAVCR2 Antibody CAB2516
€139 - €419
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Description

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Antibody Name:Anti-TIM-3/HAVCR2 Antibody
Antibody SKU:CAB2516
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 22-202 of human TIM-3/HAVCR2 (NP_116171.3).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:1000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:U-937, Mouse spleen, Mouse lung, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 22-202 of human TIM-3/HAVCR2 (NP_116171.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SEVE YRAE VGQN AYLP CFYT PAAP GNLV PVCW GKGA CPVF ECGN VVLR TDER DVNY WTSR YWLN GDFR KGDV SLTI ENVT LADS GIYC CRIQ IPGI MNDE KFNL KLVI KPAK VTPA PTRQ RDFT AAFP RMLT TRGH GPAE TQTL GSLP DINL TQIS TLAN ELRD SRLA NDLR DSGA TIRI G
Gene ID:84868
Uniprot:Q8TDQ0
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:16kDa/33kDa
Observed MW:45-70kDa
Synonyms:HAVCR2, CD366, HAVcr-2, KIM-3, TIM3, TIMD-3, TIMD3, Tim-3
Background:The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
UniProt Protein Function:TIM-3: Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9. Belongs to the immunoglobulin superfamily. TIM family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q33.3

Cellular Component: integral to membrane

Disease: Rheumatoid Arthritis

NCBI Summary:The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]
UniProt Code:Q8TDQ0
NCBI GenInfo Identifier:311033536
NCBI Gene ID:84868
NCBI Accession:Q8TDQ0.3
UniProt Related Accession:Q8TDQ0
Molecular Weight:
NCBI Full Name:Hepatitis A virus cellular receptor 2
NCBI Synonym Full Names:hepatitis A virus cellular receptor 2
NCBI Official Symbol:HAVCR2  
NCBI Official Synonym Symbols:TIM3; CD366; KIM-3; SPTCL; TIMD3; Tim-3; TIMD-3; HAVcr-2  
NCBI Protein Information:hepatitis A virus cellular receptor 2
UniProt Protein Name:Hepatitis A virus cellular receptor 2
UniProt Synonym Protein Names:T-cell immunoglobulin and mucin domain-containing protein 3; TIMD-3; T-cell immunoglobulin mucin receptor 3; TIM-3; T-cell membrane protein 3
UniProt Gene Name:HAVCR2  
UniProt Entry Name:HAVR2_HUMAN
Anti-TIM-3/HAVCR2 Antibody (CAB2516)Western blot analysis of extracts of various cell lines, using TIM-3/HAVCR2 antibody (CAB2516) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 5s.
Anti-TIM-3/HAVCR2 Antibody (CAB2516)Immunohistochemistry of paraffin-embedded human lung cancer using TIM-3/HAVCR2 antibody (CAB2516) at dilution of 1:200 (40x lens).
Anti-TIM-3/HAVCR2 Antibody (CAB2516)Immunohistochemistry of paraffin-embedded human tonsil using TIM-3/HAVCR2 antibody (CAB2516) at dilution of 1:200 (40x lens).
Anti-TIM-3/HAVCR2 Antibody (CAB2516)Immunohistochemistry of paraffin-embedded mouse spleen using TIM-3/HAVCR2 antibody (CAB2516) at dilution of 1:200 (40x lens).

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