Human TIM-3/HAVCR2 Recombinant Protein (RPES4563)
- SKU:
- RPES4563
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Immunology
Frequently bought together:
Description
system_update_altDatasheet
Human TIM-3/HAVCR2 Recombinant Protein
T-Cell Membrane Protein 3 (TIM3) is a single-pass type I membrane protein that belongs to the TIM family of immunoglobulin superfamily. TIM3 includes a signal sequence (aa 1-21); an extracellular region (aa 22-202) with one Ig-like V-type domain; a transmembrane segment (aa 203-223); and a cytoplasmic domain (aa 224 - 301). TIM3 regulates macrophage activation; inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. It may be also involved in T-cell homing and as a receptor for LGALS9.
| Product Name: | Human TIM-3/HAVCR2 Recombinant Protein (RPES4563) |
| Product Code: | RPES4563 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Hepatitis A Virus Cellular Receptor 2, HAVcr-2, T-Cell Immunoglobulin and Mucin Domain-Containing Protein 3, TIMD-3, T-Cell Membrane Protein 3, TIM-3, HAVCR2, TIM3, TIMD3 |
| Accession: | Q8TDQ0 |
| Sequence: | Ser22-Arg200 (Arg140Leu) |
| Fusion tag: | C-His |
| Activity: | Immobilized Human Galectin-9-GST at 2µg/ml(100 ?l/well) can bind Human TIM-3-His. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human TIM-3 is produced by our Mammalian expression system and the target gene encoding Ser22-Arg200 (Arg140Leu) is expressed with a 6His tag at the C-terminus. |
| Purity: | > 95% as determined by reducing SDS-PAGE. |
| Mol Mass: | 20.86 kDa |
| AP Mol Mass: | 37 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of 20mM PB; 150mM NaCl; pH 7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
