HCN1 Antibody (PACO18047)
- SKU:
- PACO18047
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | HCN1 Antibody (PACO18047) |
| Antibody SKU: | PACO18047 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human HCN1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO18047(HCN1 Antibody) at dilution 1/80, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human brain malignant glioma tissue, mouse brain tissue, Primary antibody: PACO18047(HCN1 Antibody) at dilution 1/1500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO18047(HCN1 Antibody) at dilution 1/80, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. |
| Synonyms: | hyperpolarization activated cyclic nucleotide-gated potassium channel 1 |
| UniProt Protein Function: | HCN1: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. May mediate responses to sour stimuli. Belongs to the potassium channel HCN family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 5p12 Cellular Component: axon; integral to plasma membrane; dendrite; integral to membrane; plasma membrane Molecular Function:identical protein binding; voltage-gated potassium channel activity; intracellular cAMP activated cation channel activity; potassium channel activity; voltage-gated sodium channel activity; cAMP binding Biological Process: synaptic transmission; regulation of membrane potential; apical protein localization; retinal cone cell development; potassium ion transport Disease: Epileptic Encephalopathy, Early Infantile, 24 |
| NCBI Summary: | The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. [provided by RefSeq, Oct 2011] |
| UniProt Code: | O60741 |
| NCBI GenInfo Identifier: | 229462966 |
| NCBI Gene ID: | 348980 |
| NCBI Accession: | O60741.3 |
| UniProt Related Accession: | O60741 |
| Molecular Weight: | 890 |
| NCBI Full Name: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 |
| NCBI Synonym Full Names: | hyperpolarization activated cyclic nucleotide-gated potassium channel 1 |
| NCBI Official Symbol: | HCN1 |
| NCBI Official Synonym Symbols: | BCNG1; HAC-2; BCNG-1; EIEE24 |
| NCBI Protein Information: | potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1; brain cyclic nucleotide gated channel 1; brain cyclic nucleotide-gated channel 1 |
| UniProt Protein Name: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 |
| UniProt Synonym Protein Names: | Brain cyclic nucleotide-gated channel 1; BCNG-1 |
| Protein Family: | Anaphase-promoting complex |
| UniProt Gene Name: | HCN1 |
| UniProt Entry Name: | HCN1_HUMAN |
Related Products
Anti-HCN1 Antibody (CAB17279)
€139 - €469
OverviewAntibody Name:Anti-HCN1 Antibody (CAB17279)Antibody SKU:CAB17279Antibody Size:50µL, 100µLApplication:Western blottingReactivity
CAB17279
