HCN2 Antibody [S71] is a mouse recombinant monoclonal antibody directed against HCN2, offered by Assay Genie for research applications. Reported applications include WB, IHC, ICC/IF, IP and AM. Reported reactivity: Mouse and Rat. Supplied as IgG1, purified by Protein G.
HCN2 is a member of the hyperpolarization-activated cyclic nucleotide-gated (HCN) channel family, widely expressed in both the central and peripheral nervous systems. It contributes to the generation of pacemaker currents (I_h) that regulate neuronal excitability, rhythmic firing, and synaptic transmission. In the brain, HCN2 is particularly important for maintaining the excitability of thalamocortical and hippocampal neurons. Dysregulation of HCN2 has been implicated in several neurological and neurodegenerative disorders, including epilepsy, chronic pain, and Parkinson’s disease. HCN2 dysfunction can lead to abnormal neuronal firing patterns, increased susceptibility to seizures, and impaired sensory processing. In neurodegenerative contexts, altered HCN2 expression may exacerbate network instability and contribute to cognitive and motor deficits. Additionally, HCN2 channels are modulated by cyclic nucleotides such as cAMP, linking them to intracellular signaling pathways that are often disrupted in neurodegeneration. Their role in regulating neuronal excitability and plasticity makes HCN2 a promising candidate for therapeutic modulation in diseases characterized by circuit dysfunction and progressive neuronal loss. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
HCN2 Antibody [S71]
Product SKU:
STMA00084
Size:
100 µg
Target:
HCN2
Host Species:
Mouse
Antibody Type:
Recombinant Monoclonal
Clone ID:
S71
Research Areas:
Neuroscience, Ion Channels, Cyclic Nucleotide-Gated Ion Channels, cardiovascular System, Heart
Buffer:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage & Shipping:
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, IHC, ICC/IF, IP, AM
Antibody Isotype:
IgG1
Purification:
Protein G Purified
Concentration:
1 mg/ml
Reactivity:
Mouse, Rat
Recommended Dilution:
WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Specificity:
Detects ~95kDa. No cross-reactivity against HCN1.
Guarantee:
12 months from date of dispatch
Immunogen:
Fusion protein amino acids 761-863 (cytoplasmic C-terminus) of rat HCN2
1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.:Sunderland, MA USA. 2. www.iochannels.org 3. Zong X., et al. (2005) J Biol Chem. 280(40): 34224-34232
