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HMBS Rabbit Polyclonal Antibody (CAB1777)

SKU:
CAB1777
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:HMBS Rabbit Polyclonal Antibody
SKU:CAB1777
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-361 of human HMBS (NP_000181.2).
Sequence:MSGN GNAA ATAE ENSP KMRV IRVG TRKS QLAR IQTD SVVA TLKA SYPG LQFE IIAM STTG DKIL DTAL SKIG EKSL FTKE LEHA LEKN EVDL VVHS LKDL PTVL PPGF TIGA ICKR ENPH DAVV FHPK FVGK TLET LPEK SVVG TSSL RRAA QLQR KFPH LEFR SIRG NLNT RLRK LDEQ QEFS AIIL ATAG LQRM GWHN RVGQ ILHP EECM YAVG QGAL GVEV RAKD QDIL DLVG VLHD PETL LRCI AERA FLRH LEGG CSVP VAVH TAMK DGQL YLTG GVWS LDGS DSIQ ETMQ ATIH VPAQ HEDG PEDD PQLV GITA RNIP RGPQ LAAQ NLGI SLAN LLLS KGAK NILD VARQ LNDA H
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:UPS; PBGD; PORC; PBG-D; HMBS
Positive Sample:HeLa,Raji,Mouse spleen
Conjugate:Unconjugated
Cellular Localization:Cytoplasm.
Calculated MW:39kDa
Observed MW:45kDa

This gene encodes a member of the hydroxymethylbilane synthase superfamily. The encoded protein is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria. Alternatively spliced transcript variants encoding different isoforms have been described.

Purification Method:Affinity purification
Gene ID:3145
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using HMBS antibody (CAB1777) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.

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