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Anti-HSD17B1 Antibody (CAB10839)

SKU:
CAB10839
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism
  • Metabolism Antibodies 1 Anti-HSD17B1 Antibody CAB10839
  • Metabolism Antibodies 1 Anti-HSD17B1 Antibody CAB10839
  • Metabolism Antibodies 1 Anti-HSD17B1 Antibody CAB10839
  • Metabolism Antibodies 1 Anti-HSD17B1 Antibody CAB10839
  • Metabolism Antibodies 1 Anti-HSD17B1 Antibody CAB10839
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-HSD17B1 Antibody
Antibody SKU:CAB10839
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-328 of human HSD17B1 (NP_000404.2).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, Rat ovary
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-328 of human HSD17B1 (NP_000404.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MART VVLI TGCS SGIG LHLA VRLA SDPS QSFK VYAT LRDL KTQG RLWE AARA LACP PGSL ETLQ LDVR DSKS VAAA RERV TEGR VDVL VCNA GLGL LGPL EALG EDAV ASVL DVNV VGTV RMLQ AFLP DMKR RGSG RVLV TGSV GGLM GLPF NDVY CASK FALE GLCE SLAV LLLP FGVH LSLI ECGP VHTA FMEK VLGS PEEV LDRT DIHT FHRF YQYL AHSK QVFR EAAQ NPEE VAEV FLTA LRAP KPTL RYFT TERF LPLL RMRL DDPS GSNY VTAM HREV FGDV PAKA EAGA EAGG GAGP GAED EAGR GAVG DPEL GDPP AAPQ
Gene ID:3292
Uniprot:P14061
Cellular Location:Cytoplasm
Calculated MW:34kDa
Observed MW:35kDa
Synonyms:HSD17B1, 17-beta-HSD, 20-alpha-HSD, E2DH, EDH17B2, EDHB17, HSD17, SDR28C1
Background:
UniProt Protein Function:HSD17B1: Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
UniProt Protein Details:

Protein type:Lipid Metabolism - androgen and estrogen; EC 1.1.1.62; Oxidoreductase

Chromosomal Location of Human Ortholog: 17q11-q21

Cellular Component: nucleoplasm; nuclear membrane; cytoplasm; cytosol

Molecular Function:estradiol 17-beta-dehydrogenase activity; catalytic activity; 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity

Biological Process: steroid metabolic process; estrogen metabolic process; steroid biosynthetic process; estrogen biosynthetic process

UniProt Code:P14061
NCBI GenInfo Identifier:313104233
NCBI Gene ID:3292
NCBI Accession:P14061.3
UniProt Secondary Accession:P14061,Q2M2L8, B3KXS1,
UniProt Related Accession:P14061
Molecular Weight:34,950 Da
NCBI Full Name:Estradiol 17-beta-dehydrogenase 1
NCBI Synonym Full Names:hydroxysteroid (17-beta) dehydrogenase 1
NCBI Official Symbol:HSD17B1  
NCBI Official Synonym Symbols:HSD17; EDHB17; EDH17B2; SDR28C1  
NCBI Protein Information:estradiol 17-beta-dehydrogenase 1; E2DH; 20-alpha-HSD; 17-beta-HSD 1; estradiol 17-beta-dehydrogenase-1; 20 alpha-hydroxysteroid dehydrogenase; 17-beta-hydroxysteroid dehydrogenase type 1; placental 17-beta-hydroxysteroid dehydrogenase; hydroxysteroid (17-beta) dehydrogenase 1 isoform; short chain dehydrogenase/reductase family 28CE, member 1
UniProt Protein Name:Estradiol 17-beta-dehydrogenase 1
UniProt Synonym Protein Names:17-beta-hydroxysteroid dehydrogenase type 1; 17-beta-HSD 1; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; E2DH; Placental 17-beta-hydroxysteroid dehydrogenase
Protein Family:Estradiol 17-beta-dehydrogenase
UniProt Gene Name:HSD17B1  
UniProt Entry Name:DHB1_HUMAN
Anti-HSD17B1 Antibody (CAB10839)Western blot analysis of extracts of various cell lines, using HSD17B1 antibody (CAB10839) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
Anti-HSD17B1 Antibody (CAB10839)Immunohistochemistry of paraffin-embedded human placenta using HSD17B1 antibody (CAB10839) at dilution of 1:100 (40x lens).
Anti-HSD17B1 Antibody (CAB10839)Immunohistochemistry of paraffin-embedded mouse heart using HSD17B1 antibody (CAB10839) at dilution of 1:100 (40x lens).
Anti-HSD17B1 Antibody (CAB10839)Immunofluorescence analysis of C6 cells using HSD17B1 Polyclonal Antibody (CAB10839) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Anti-HSD17B1 Antibody (CAB10839)Immunofluorescence analysis of HeLa cells using HSD17B1 Polyclonal Antibody (CAB10839) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

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