HSP110 Antibody is a rabbit polyclonal antibody directed against HSP110, offered by Assay Genie for research applications. Reported applications include WB, IHC and ICC/IF. Reported reactivity: Human, Mouse, Rat, Bovine, Monkey, Hamster, Sheep, Yeast, Shark, Gummy Shark (Mustelus antarcticus) and School Shark (Galeorhinus galeus). Purified by Protein A.
HSP110, a member of the HSP110/SSE family of large stress proteins, plays a critical role in maintaining proteostasis under physiological and pathological conditions. Although distantly related to the HSP70 family, HSP110 shares 30–33% amino acid identity, particularly within the conserved ATP-binding domain, and functions cooperatively with HSP70 in the eukaryotic cytosol to facilitate protein folding and prevent aggregation. In mammals, HSP110 is constitutively expressed, with notably high levels in the brain. Its expression is further upregulated in response to cellular stress, including cerebral ischemia—a condition closely linked to neurodegenerative processes. Both HSP70 and HSP110 are elevated following ischemic events, suggesting a coordinated chaperone response. Interestingly, HSP110 deficiency has been associated with enhanced HSP70 activity, indicating a compensatory mechanism that may influence neuronal survival and recovery. Emerging evidence positions HSP110 as a key modulator of neuroprotection, particularly in the context of diseases characterized by protein misfolding and aggregation, such as Alzheimer’s, Parkinson’s, and Huntington’s disease. By stabilizing protein conformation and supporting cellular stress responses, HSP110 contributes to neuronal resilience and recovery. Beyond neuroscience, HSP110 is also being explored in cancer immunotherapy, highlighting its broader relevance in stress biology and therapeutic development. Its dual role in neuroprotection and immune modulation makes HSP110 a promising target in translational research focused on neurodegenerative disease intervention. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
HSP110 Antibody
Product SKU:
STPA00037
Size:
100 µg
Target:
HSP110
Host Species:
Rabbit
Antibody Type:
Polyclonal
Research Areas:
Cancer, Heat Shock, Cell Signaling, Protein Trafficking, Chaperone Proteins
Buffer:
PBS pH7.2, 50% glycerol, 0.09% sodium azide
Storage & Shipping:
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, IHC, ICC/IF
Purification:
Protein A Purified
Concentration:
1 mg/ml
Reactivity:
Human, Mouse, Rat, Bovine, Monkey, Hamster, Sheep, Yeast, Shark, Gummy Shark (Mustelus antarcticus), School Shark (Galeorhinus galeus)
Recommended Dilution:
WB (1:1000), IHC (1:100); optimal dilutions for assays should be determined by the user.
Specificity:
Detects ~110kDa.
Guarantee:
12 months from date of dispatch
Immunogen:
Synthetic peptide derived from the sequence of hamster HSP110; sequence identical to human and mouse
Immunogen Species:
Hamster
Accession Number:
NP_006635.3
Gene ID:
10808
Swiss-Prot:
Q92599
Cellular Localization:
Cytoplasm
Alternative Names:
HSPH1, HSP110, HSP105, Heat shock protein 105 kDa, Heat shock 110 kDa protein, KIAA0201, Heat shock 105kDa alpha, heat shock 105kDa beta, HSP105A, HSP105B, NY CO 25
References:
1. Lee-Yoon D., et al. (1995) J Biol Chem. 270: 15725-15733. 2. Dragovic Z., et al. (2006) EMBO J. 25: 2519-2528. 3. Nakamura J., et al. (2008) Stroke. 39(10): 2853-2859. 4. Subject D.R. (2001) Health Research Inc. Report number AS90893: 1-84.
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