Description
Human ABCC4 Recombinant Protein (N-His)
Human ABCC4 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Ile1041-Gln1274, with an N-terminal His tag. Predicted molecular weight: 28.84 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. ATP-binding cassette sub-family C member 4 (ABCC4) is a ~149 kDa protein. ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. For research use only.
Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). 1. van Aubel, RAMH. et al. (2002) Journal of the American Society of Nephrology : JASN 13, 595-603. PMID: 11856762 2. Zelcer, N. et al. (2003) The Biochemical journal 371, 361-7. PMID: 12523936 3. Sauna, ZE. et al. (2004) The Journal of biological chemistry 279, 48855-64. PMID: 15364914 4. Zhu, Y. et al. (2024) FEBS letters 598, 1967-1980. PMID: 38886124 5. Xie, Z. et al. (2025) Cell reports 44, 115466. PMID: 40138312 6. Reid, G. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 9244-9. PMID: 12835412 7. Rius, M. et al. (2003) Hepatology (Baltimore, Md.) 38, 374-84. PMID: 12883481
| Product Name: | Human ABCC4 Recombinant Protein (N-His) |
| SKU: | GXRP00127 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | MOAT-B, MOATB, Multi-specific organic anion transporter B, ATP-binding cassette sub-family C member 4, Multidrug resistance-associated protein 4, MRP4, ABCC4, MRP/cMOAT-related ABC transporter |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Ile1041-Gln1274 |
| Calculated MW: | 28.84 kDa |
| UniProt: | O15439 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
