Description
Human ABRAXAS2 Recombinant Protein (N-His)
Human ABRAXAS2 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Met1-Ile158, with an N-terminal His tag. Predicted molecular weight: 20.71 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. BRISC complex subunit Abraxas 2 is a ~46 kDa protein. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates. For research use only.
May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm. Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins. Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression.
| Product Name: | Human ABRAXAS2 Recombinant Protein (N-His) |
| SKU: | GXRP09703 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | BRISC complex subunit Abraxas 2; Abraxas brother protein 1; Protein FAM175B; ABRAXAS2; ABRO1; FAM175B; KIAA0157 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Met1-Ile158 |
| Calculated MW: | 20.71 kDa |
| UniProt: | Q15018 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
