Description
Human ACO1 Recombinant Protein (N-His)
Human ACO1 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Lys26-Ile243, with an N-terminal His tag. Predicted molecular weight: 26.95 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Cytoplasmic aconitate hydratase (ACO1) is a ~98 kDa protein. Bifunctional iron sensor that switches between 2 activities depending on iron availability. For research use only.
Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization. Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA.
| Product Name: | Human ACO1 Recombinant Protein (N-His) |
| SKU: | GXRP01182 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Ferritin repressor protein, IRP1, ACO1, IREB1, Citrate hydro-lyase, IRE-BP 1, Iron-responsive element-binding protein 1, Aconitase, Cytoplasmic aconitate hydratase, Iron regulatory protein 1 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Lys26-Ile243 |
| Calculated MW: | 26.95 kDa |
| UniProt: | P21399 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
