Description
Human ACVR1B Recombinant Protein (N-His)
Human ACVR1B Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Ser24-Glu126, with an N-terminal His tag. Predicted molecular weight: 13.71 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Activin receptor type-1B (ACVR1B) is a ~56 kDa protein. Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). For research use only.
Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase.
| Product Name: | Human ACVR1B Recombinant Protein (N-His) |
| SKU: | GXRP01519 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Activin receptor-like kinase 4, SKR2, ACVRLK4, ACVR1B, ALK-4, Activin receptor type IB, Activin receptor type-1B, Serine/threonine-protein kinase receptor R2, ACTR-IB, ALK4 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Ser24-Glu126 |
| Calculated MW: | 13.71 kDa |
| UniProt: | P36896 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
