Description
Human ACVR1C Recombinant Protein (N-His)
Human ACVR1C Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Thr166-Ala493, with an N-terminal His tag. Predicted molecular weight: 39.42 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Activin receptor type-1C is a ~54 kDa protein. Serine/threonine protein kinase which forms a receptor complex on ligand binding. For research use only.
The receptor complex consists of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B, activin E and NODAL. Upon NODAL binding, activation results in increased apoptosis and reduced proliferation through suppression of AKT signaling and the activation of Smad2-dependent signaling pathway in pancreatic beta-cells, trophoblasts, epithelial or neuronal cells.
| Product Name: | Human ACVR1C Recombinant Protein (N-His) |
| SKU: | GXRP12201 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | ACTR-IC, ACVR1C, ALK-7, ALK7, Activin receptor type IC, Activin receptor type-1C, Activin receptor-like kinase 7, EC:2.7.11.30 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Thr166-Ala493 |
| Calculated MW: | 39.42 kDa |
| UniProt: | Q8NER5 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
