Description
Human AICDA Recombinant Protein (N-His)
Human AICDA Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Gly23-Leu183, with an N-terminal His tag. Predicted molecular weight: 21.65 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Single-stranded DNA cytosine deaminase (AICDA) is a ~23 kDa protein. Single-stranded DNA-specific cytidine deaminase. For research use only.
Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
| Product Name: | Human AICDA Recombinant Protein (N-His) |
| SKU: | GXRP02840 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Single-stranded DNA cytosine deaminase, AICDA, Activation-induced cytidine deaminase, AID, Cytidine aminohydrolase |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Gly23-Leu183 |
| Calculated MW: | 21.65 kDa |
| UniProt: | Q9GZX7 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
