Human AKR1B10 Recombinant Protein (RPPB5793)
- SKU:
- RPPB5793
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O60218
- Research Area:
- Enzymes
Description
| Product Name: | Human AKR1B10 Recombinant Protein |
| Product Code: | RPPB5793 |
| Size: | 20µg |
| Species: | Human |
| Target: | AKR1B10 |
| Synonyms: | HIS, HSI, ARL1, ARL-1, ALDRLn, AKR1B11, AKR1B12, MGC14103, AKR1B10, Aldo-keto reductase family 1 member B10, Aldose reductase-like, Aldose reductase-related protein, ARP, hARP, Small intestine reductase, SI reductase. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear colorless solution. |
| Formulation: | The AKR1B10 solution contains 20mM Tris-HCl pH-8 and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MATFVELSTK AKMPIVGLGT WKSPLGKVKE AVKVAIDAGY RHIDCAYVYQ NEHEVGEAIQ EKIQEKAVKR EDLFIVSKLW PTFFERPLVRKAFEKTLKDL KLSYLDVYLI HWPQGFKSGD DLFPKDDKGN AIGGKATFLD AWEAMEELVD EGLVKALGVS NFSHFQIEKL LNKPGLKYKP VTNQVECHPY LTQEKLIQYC HSKGITVTAY SPLGSPDRPW AKPEDPSLLE DPKIKEIAAK HKKTAAQVLI RFHIQRNVIV IPKSVTPARIVENIQVFDFK LSDEEMATIL SFNRNWRACN VLQSSHLEDY PFDAEY |
AKR1B10 efficiently reduces aliphatic and aromatic aldehydes, and it is less active on hexoses. AKR1B10 is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. AKR1B10 is a monomeric protein that competently catalyzes the reduction of aromatic and aliphatic aldehydes and ketones. AKR1B10 is widely expressed in numerous human tissues, small intestine, colon and adrenal gland. AKR1B10 is pathogenically involved in diabetic complications and is overexpressed in human tumors, such as liver, breast, and lung cancer, AKR1B10 is involved in the development and progression of cancer.
AKR1B10 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 316 amino acids (1-316 a.a) and having a molecular mass of 36 kDa. The AKR1B10 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | AKR1B10: Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. Belongs to the aldo/keto reductase family. |
| UniProt Protein Details: | Protein type:Lipid Metabolism - linoleic acid; Oxidoreductase; EC 1.1.1.21; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - fructose and mannose; EC 1.1.1.- Chromosomal Location of Human Ortholog: 7q33 Cellular Component: cytosol Molecular Function:aldo-keto reductase activity; geranylgeranyl reductase activity; indanol dehydrogenase activity; protein binding; retinal dehydrogenase activity Biological Process: aldehyde metabolic process; digestion; farnesol catabolic process; retinoid metabolic process; steroid metabolic process |
| NCBI Summary: | This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O60218 |
| NCBI GenInfo Identifier: | 322510010 |
| NCBI Gene ID: | 57016 |
| NCBI Accession: | O60218.2 |
| UniProt Secondary Accession: | O60218,O75890, Q6FHF3, Q8IWZ1, A4D1P1, |
| UniProt Related Accession: | O60218 |
| Molecular Weight: | 36,020 Da |
| NCBI Full Name: | Aldo-keto reductase family 1 member B10 |
| NCBI Synonym Full Names: | aldo-keto reductase family 1 member B10 |
| NCBI Official Symbol: | AKR1B10�� |
| NCBI Official Synonym Symbols: | HIS; HSI; ARL1; ARL-1; ALDRLn; AKR1B11; AKR1B12�� |
| NCBI Protein Information: | aldo-keto reductase family 1 member B10 |
| UniProt Protein Name: | Aldo-keto reductase family 1 member B10 |
| UniProt Synonym Protein Names: | ARL-1; Aldose reductase-like; Aldose reductase-related protein; ARP; hARP; Small intestine reductase; SI reductase |
| Protein Family: | Aldo-keto reductase family |
| UniProt Gene Name: | AKR1B10�� |
| UniProt Entry Name: | AK1BA_HUMAN |
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