The secreted protein GDF-11 (growth/differentiation factor 11) is a transforming growth factor beta superfamily member. By modulating the activity of Hox genes, GDF-11 controls anterior-posterior patterning. During development, the secreted signal acts globally to identify positional identity along the anterior/posterior axis. GDF11 blocks neurogenesis by inhibiting progenitor cell-cycle progression through a mechanism that is similar to myostatin's. GDF11 and myostatin are similar owing to their ties with tissue growth and development, suggesting that the same regulatory mechanisms may be used to regulate both muscular and neural growth. Human GDF11/BMP1 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Human GDF11/BMP1 Recombinant Protein (RPES0139)
Product Code:
RPES0139
Size:
10µg
Species:
Human
Expressed Host:
Human Cells
Synonyms:
Growth/differentiation factor 11,GDF-11,Bone morphogenetic protein 11,BMP-11
Accession:
O95390
Sequence:
Asn299-Ser407
Fusion tag:
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human Growth differentiation factor 11 is produced by our Mammalian expression system and the target gene encoding Asn299-Ser407 is expressed.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
12.6 kDa
AP Mol Mass:
14 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
