Description
Human APOBEC3C Recombinant Protein (N-His)
Human APOBEC3C Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Met12-Gln190, with an N-terminal His tag. Predicted molecular weight: 23.71 kDa. Purity: >95% as determined by SDS-PAGE. Supplied lyophilized from PBS pH7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. DNA dC->dU-editing enzyme APOBEC-3C (ABC3C) is a ~22 kDa protein. DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. For research use only.
After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons.
| Product Name: | Human APOBEC3C Recombinant Protein (N-His) |
| SKU: | GXRP08454 |
| Size: | 50 µg, 100 µg, 1 mg |
| Synonyms: | DNA dC->dU-editing enzyme APOBEC-3C, A3C, EC:3.5.4.38, APOBEC1-like, Phorbolin I, APOBEC3C |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Met12-Gln190 |
| Calculated MW: | 23.71 kDa |
| UniProt: | Q9NRW3 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >95% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from PBS pH7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
