Description
Human ARPP19 Recombinant Protein (N-His-SUMO & C-Strep)
Human ARPP19 Recombinant Protein (N-His-SUMO & C-Strep) is a recombinant protein expressed in E. coli, spanning Ser2-Leu77, with an N-terminal His-SUMO tag and a C-terminal Strep tag. Predicted molecular weight: 22.08 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. cAMP-regulated phosphoprotein 19 (ARPP19) is a ~12 kDa protein. Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. For research use only.
Inhibition of PP2A is enhanced when ARPP19 is phosphorylated. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression.
| Product Name: | Human ARPP19 Recombinant Protein (N-His-SUMO & C-Strep) |
| SKU: | GXRP04989 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | cAMP-regulated phosphoprotein 19, ARPP19, ARPP-19 |
| Tag: | N-His-SUMO & C-Strep |
| Expression Host: | E. coli |
| Protein Length: | Ser2-Leu77 |
| Calculated MW: | 22.08 kDa |
| UniProt: | P56211 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
