Description
Human ASPM Recombinant Protein (N-His)
Human ASPM Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Leu940-Leu1261, with an N-terminal His tag. Predicted molecular weight: 39.08 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Abnormal spindle-like microcephaly-associated protein (ASPM) is a ~409 kDa protein. Involved in mitotic spindle regulation and coordination of mitotic processes. For research use only.
The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex. May have a preferential role in regulating neurogenesis.
| Product Name: | Human ASPM Recombinant Protein (N-His) |
| SKU: | GXRP06726 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | MCPH5, Abnormal spindle-like microcephaly-associated protein, ASPM, Abnormal spindle protein homolog, Asp homolog |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Leu940-Leu1261 |
| Calculated MW: | 39.08 kDa |
| UniProt: | Q8IZT6 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
