Description
Human BACE2 Recombinant Protein (N-His)
Human BACE2 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Met230-Phe396, with an N-terminal His tag. Predicted molecular weight: 20.85 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Beta-secretase 2 (BACE2) is a ~56 kDa protein. Responsible for the proteolytic processing of the amyloid precursor protein (APP). For research use only.
Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus.
| Product Name: | Human BACE2 Recombinant Protein (N-His) |
| SKU: | GXRP03525 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Aspartyl protease 1, Membrane-associated aspartic protease 1, Beta-secretase 2, ASP21, BACE2, Asp 1, ALP56, Beta-site APP cleaving enzyme 2, Aspartic-like protease 56 kDa, Beta-site amyloid precursor protein cleaving enzyme 2, Down region aspartic protease, Theta-secretase, Memapsin-1, AEPLC, ASP1, DRAP |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Met230-Phe396 |
| Calculated MW: | 20.85 kDa |
| UniProt: | Q9Y5Z0 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
