Description
Human BARD1 Recombinant Protein (N-His)
Human BARD1 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Asn419-Ser777, with an N-terminal His tag. Predicted molecular weight: 42.76 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. BRCA1-associated RING domain protein 1 is a ~86 kDa protein. E3 ubiquitin-protein ligase. For research use only.
The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.
| Product Name: | Human BARD1 Recombinant Protein (N-His) |
| SKU: | GXRP11668 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | BARD-1, BARD1, BRCA1-associated RING domain protein 1, EC:2.3.2.27, RING-type E3 ubiquitin transferase BARD1 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Asn419-Ser777 |
| Calculated MW: | 42.76 kDa |
| UniProt: | Q99728 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
