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Human BCRP / ABCG2 ELISA Kit

SKU:
HUFI00843
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
Q9UNQ0
Sensitivity:
0.094ng/ml
Range:
0.156-10ng/ml
ELISA Type:
Sandwich
Synonyms:
ABCG2, ATP Binding Cassette Transporter G2, ABCP, BCRP, CD338, MXR, ABC transporter, ABC15, ATP-binding cassette sub-family G member 2, ATP-binding cassette, sub-family G, WHITE, member 2, BCRP1, BCRPMRX, BMDP, Breast cancer resistance protein, CDw33
Reactivity:
Human
Research Area:
Signal Transduction
€599
Frequently bought together:

Description

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Human BCRP / ABCG2 ELISA Kit

BCRP/ABCG2 belongs to the superfamily of ATP-binding cassette (ABC) transporters, which transports different molecules across extra- and intra-cellular membranes. There are seven major groups of ABC genes, each with its own distinct subfamily (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). ABCG2 is a member of the White subfamily. ABCG2 functions as a xenobiotic transporter that may play an important part in multi-drug resistance. Mitoxantrone and anthracycline exposure might trigger it to function as a cellular protection mechanism. ABCG2 is highly expressed in the placenta, which might suggest that it has an important role in placental tissue. Uric acid concentration, and blood disorders are some of the diseases linked to ABCG2. Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics and Erlotinib Pathway are among BCRP/ABCG2 associated pathways.