Description
Human BRIP1 Recombinant Protein (N-His)
Human BRIP1 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Ile243-Asn595, with an N-terminal His tag. Predicted molecular weight: 43.05 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Fanconi anemia group J protein is a ~140 kDa protein. DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability. For research use only.
Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease. Can unwind RNA:DNA substrates.
| Product Name: | Human BRIP1 Recombinant Protein (N-His) |
| SKU: | GXRP11661 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | BACH1, BRCA1-associated C-terminal helicase 1, BRCA1-interacting protein 1, BRCA1-interacting protein C-terminal helicase 1, BRIP1, DNA 5'-3' helicase FANCJ, EC:5.6.2.3, FANCJ, Fanconi anemia group J protein |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Ile243-Asn595 |
| Calculated MW: | 43.05 kDa |
| UniProt: | Q9BX63 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
