Description
Human CADM-140/MDA5 Recombinant Protein
Human CADM-140/MDA5 Recombinant Protein is a recombinant protein expressed in confidential, spanning Confidential. Predicted molecular weight: 118.04 kDa. Purity: >95% as determined by SDS-PAGE. Supplied as a liquid in 20 mM Tris-HCl, pH 8.0, 100mM NaCl, 1mM DTT, 10% Glycerol. Interferon-induced helicase C domain-containing protein 1 is a ~116 kDa protein. Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and pro-inflammatory cytokines. For research use only.
Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV), mengo encephalomyocarditis virus (ENMG), and rhinovirus. Detects coronavirus SARS-CoV-2.
| Product Name: | Human CADM-140/MDA5 Recombinant Protein |
| SKU: | GXRP03560 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | MDA-5, IFIH1, Helicard, Clinically amyopathic dermatomyositis autoantigen 140 kDa, Interferon-induced with helicase C domain protein 1, Helicase with 2 CARD domains, RNA helicase-DEAD box protein 116, RIG-I-like receptor 2, Interferon-induced helicase C domain-containing protein 1, MDA5, Murabutide down-regulated protein, Melanoma differentiation-associated protein 5, CADM-140 autoantigen, RH116, RLR-2 |
| Expression Host: | Confidential |
| Protein Length: | Confidential |
| Calculated MW: | 118.04 kDa |
| UniProt: | Q9BYX4 |
| Applications: | As a diagnostic tool for Clinically Amyopathic Dermatomyositis (CADM). |
| Purity: | >95% as determined by SDS-PAGE. |
| Form: | Liquid |
| Formulation: | 20 mM Tris-HCl, pH 8.0, 100mM NaCl, 1mM DTT, 10% Glycerol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
