Description
Human CALCOCO2 Recombinant Protein (N-His)
Human CALCOCO2 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Ser21-Ser120, with an N-terminal His tag. Predicted molecular weight: 14.28 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Calcium-binding and coiled-coil domain-containing protein 2 is a ~52 kDa protein. Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. For research use only.
Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy. Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation. Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C. May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion.
| Product Name: | Human CALCOCO2 Recombinant Protein (N-His) |
| SKU: | GXRP11039 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Antigen nuclear dot 52 kDa protein, CALCOCO2, Calcium-binding and coiled-coil domain-containing protein 2, NDP52, Nuclear domain 10 protein 52, Nuclear domain 10 protein NDP52, Nuclear dot protein 52 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Ser21-Ser120 |
| Calculated MW: | 14.28 kDa |
| UniProt: | Q13137 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
