Description
Human CASP5 Recombinant Protein (N-His)
Human CASP5 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Ile182-Asp327, with an N-terminal His tag. Predicted molecular weight: 23.22 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Caspase-5 (CASP5) is a ~49 kDa protein. Thiol protease that acts as a mediator of programmed cell death. For research use only.
Initiates pyroptosis, a programmed lytic cell death pathway through cleavage of Gasdermin-D (GSDMD): cleavage releases the N-terminal gasdermin moiety (Gasdermin-D, N-terminal) that binds to membranes and forms pores, triggering pyroptosis. Also mediates cleavage and maturation of IL18. Cleavage of GSDMD and IL18 is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP4. During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation.
| Product Name: | Human CASP5 Recombinant Protein (N-His) |
| SKU: | GXRP01761 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Caspase-5, Protease ICH-3, Protease TY, ICE(rel)-III, ICH3, CASP5, CASP-5 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Ile182-Asp327 |
| Calculated MW: | 23.22 kDa |
| UniProt: | P51878 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
