Description
Human CD110/MPL Recombinant Protein (N-His)
Human CD110/MPL Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Ser311-Gln460, with an N-terminal His tag. Predicted molecular weight: 19.86 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Thrombopoietin receptor (CD110/MPL) is a ~71 kDa protein. Receptor for thrombopoietin that regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet formation. For research use only.
Upon activation by THPO, induces rapid tyrosine phosphorylation and activation of JAK2, providing docking sites for many signaling proteins such as STAT5, SHIP/INPP5D, GRB2, SOS1 and PI3K. In turn, These signaling cascades lead to the proliferation, survival, and differentiation of megakaryocytes, ultimately leading to increased platelet production.
| Product Name: | Human CD110/MPL Recombinant Protein (N-His) |
| SKU: | GXRP01551 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | TPO-R, TPOR, Thrombopoietin receptor, MPL, Myeloproliferative leukemia protein, Proto-oncogene c-Mpl, CD110 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Ser311-Gln460 |
| Calculated MW: | 19.86 kDa |
| UniProt: | P40238 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
