Human CD115/CSF1R Antibody (AMG 820) is a research-grade biosimilar monoclonal antibody. It is a human IgG2 antibody. Reactivity: Human. Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA, flow cytometry, functional assays and in vivo research. Endotoxin: < 10 EU/mg. Purity: >95% purity as determined by SDS-PAGE. For research use only.
Macrophage colony-stimulating factor 1 receptor (CD115/CSF1R) is a ~107 kDa protein. Tyrosine-protein kinase that acts as a cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion.
Product Name:
Human CD115/CSF1R Antibody (AMG 820)
SKU:
GXBS01713
Size:
100 µg, 1 mg
Antibody Type:
Monoclonal Antibody
Clone:
AMG 820
Target:
CD115
Isotype:
IgG2
Host Species:
Human
Reactivity:
Human
Applications:
ELISA, FACS, Functional assay, Research in vivo
Expression Host:
Mammalian cells
Synonyms:
AMG-820, AMG820, AMG820
Biological Activity:
AMG-820 potently inhibits CSF1-driven proliferation of human bone marrow–derived monocytic cells, as well as CSF1- and IL34-driven proliferation of myelomonocytic AML-5 cells [1].
Purity:
>95% purity as determined by SDS-PAGE.
Endotoxin Level:
< 10 EU/mg
Formulation:
0.01M PBS pH 7.4
State of Matter:
Liquid
Regulatory Status:
For research use only. Not suitable for clinical or therapeutic use.
Product Preparation:
Protein A/G purified from cell culture supernatant.
Storage and Handling:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
