Description
Human CD136/MST1R Recombinant Protein (C-His)
Human CD136/MST1R Recombinant Protein (C-His) is a recombinant protein expressed in mammalian cells, spanning Met1-Leu571, with a C-terminal His tag. Predicted molecular weight: 62.12 kDa. Purity: >95% as determined by SDS-PAGE. Supplied lyophilized from PBS pH7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: SDS-PAGE, Western blot, ELISA and immunogen. Macrophage-stimulating protein receptor (CD136/MST1R) is a ~152 kDa protein. Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. For research use only.
Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC.
| Product Name: | Human CD136/MST1R Recombinant Protein (C-His) |
| SKU: | GXRP08472 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Macrophage-stimulating protein receptor, MSP receptor, 2.7.10.1, CDw136, Protein-tyrosine kinase 8, p185-Ron, CD136, Macrophage-stimulating protein receptor alpha chain, Macrophage-stimulating protein receptor beta chain, MST1R |
| Tag: | C-His |
| Expression Host: | Mammalian cells |
| Protein Length: | Met1-Leu571 |
| Calculated MW: | 62.12 kDa |
| UniProt: | Q04912 |
| Applications: | SDS-PAGE, WB, ELISA, Immunogen |
| Purity: | >95% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from PBS pH7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
