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Human CD195/CCR5 (HGS101) Antibody - SDS-PAGE
Key Features

Human CD195/CCR5 (HGS101) Antibody (GXBS00979)

Datasheet MSDS
SKU GXBS00979
Product Type Research Grade Biosimilar
Antibody Type Monoclonal
Host Species Human
Reactivity Human
Applications ELISA, FACS, Functional assay, Research in vivo
Clone ID HGS101
Isotype IgG
$677 - $2,208

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Description

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Human CD195/CCR5 (HGS101) Antibody

Human CD195/CCR5 (HGS101) Antibody is a research-grade biosimilar monoclonal antibody. It is a human IgG antibody. Reactivity: Human. Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA, flow cytometry, functional assays and in vivo research. Endotoxin: < 10 EU/mg. Purity: >95% purity as determined by SDS-PAGE. For research use only.

C-C chemokine receptor type 5 (CD195/CCR5) is a ~40 kDa protein. Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.

Product Name:Human CD195/CCR5 (HGS101) Antibody
SKU:GXBS00979
Size:100 µg, 1 mg
Antibody Type:Monoclonal Antibody
Clone:HGS101
Target:C-C CKR-5
Isotype:IgG
Host Species:Human
Reactivity:Human
Applications:ELISA, FACS, Functional assay, Research in vivo
Expression Host:Mammalian cells
Synonyms:HGS101
Biological Activity:HGS101 (1 h) shows EC 50 values of 0.001 ug/mL for Maraviroc ()-sensitive, 0.0003 ug/mL for Maraviroc -resistant, and 0.00002 ug/mL for Maraviroc -resistant HIV-1 in the presence of Maraviroc in JC6 cells [1]. HGS101 (1 h) shows EC 50 values of 0.03 ug/mL for Maraviroc -sensitive, 0.03 ug/mL for Maraviroc -resresistant, and 0.01 ug/mL for Maraviroc -resistant HIV-1 in the presence of Maraviroc in PBMCs [1]. HGS101 (0.3 ug/ mL, 1 h) restores Maraviroc inhibition (EC 50 of 0.007 nM) of Maraviroc -resistant HIV-1 in PBMCs [1]. HGS101 (10 mg/kg, i.v., every 15 days for 10 times) shows anti-HIV activity by inhibiting CCR5 signaling in simian immunodeficiency virus-uninfected RMs models [2]. . Reduced the levels of CCR5 + T-cells in blood and lymph nodes. Induced a complex anatomic redistribution of CD25 + T-cell. Induced specific changes in the transcriptional profile of leukocytes.
Purity:>95% purity as determined by SDS-PAGE.
Endotoxin Level:< 10 EU/mg
Formulation:0.01M PBS pH 7.4
State of Matter:Liquid
Regulatory Status:For research use only. Not suitable for clinical or therapeutic use.
Product Preparation:Protein A/G purified from cell culture supernatant.
Storage and Handling:Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
UniProt:P51681
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