Description

PE Anti-Human CD196/CCR6 Antibody [G034E3]

The Human CD196 (CCR6) Monoclonal Antibody (PE Conjugated) is a cutting-edge tool designed for researchers in the fields of immunology and cell biology. This advanced antibody, labeled with phycoerythrin (PE), specifically targets the CD196 (CCR6) protein, a key chemokine receptor involved in immune cell migration and homeostasis.With its high specificity and sensitivity, this antibody is ideal for use in flow cytometry applications, enabling precise detection and analysis of CD196 (CCR6) expression in various cell populations. Researchers can rely on its superior performance in identifying and characterizing immune cells expressing CD196 (CCR6), providing valuable insights into immune responses, inflammation, and potential therapeutic targets.

The CD196 (CCR6) protein is known for its role in mediating leukocyte recruitment to inflamed tissues and regulating immune responses. By utilizing this monoclonal antibody, researchers can further explore the functions and interactions of CD196 (CCR6) in various physiological and pathological conditions, including autoimmune diseases, inflammatory disorders, and infectious processes.In summary, the Human CD196 (CCR6) Monoclonal Antibody (PE Conjugated) from AssayGenie offers a powerful tool for investigating the intricate mechanisms of immune cell signaling and migration, paving the way for groundbreaking discoveries in immunology research and drug development.

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Product Title:	PE Anti-Human CD196/CCR6 Antibody [G034E3]
SKU:	AGEL1800
Size:	20 Tests, 100 Tests, 200 Tests
Clone No:	G034E3
Synonyms:	CKRL3; CMKBR6; GPR29; STRL22;GPRCY4;
Host Species:	Mouse
Reactivity:	Human
Application:	FCM

Isotype:	Mouse IgG2b, κ
Isotype Control:	PE Mouse IgG2b, κ Isotype Control[MPC-11]
Form:	Liquid
Conjugation:	PE
Recommended Use:	Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:

Swissprot:	P51684
Gene ID:	1235
Storage Buffer:	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:	Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:	CCR6, also known as CD196/CCR6, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6 binds CCL20, although members of the β defensin family also bind CCR6 with a lower affinity. CCR6 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers Patches (PPs) and isolated lymphoid follicles (ILFs). CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues.

PE Anti-Human CD196/CCR6 Antibody [G034E3] (AGEL1800)

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