Human CD277/BTN3A1 Antibody (CTX 2026) is a research-grade biosimilar monoclonal antibody. It is a human IgG2 antibody. Reactivity: Human. Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA, flow cytometry, functional assays and in vivo research. Endotoxin: < 10 EU/mg. Purity: >95% purity as determined by SDS-PAGE. For research use only.
Butyrophilin subfamily 3 member A1 (CD277/BTN3A1) is a ~57 kDa protein. Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.
Product Name:
Human CD277/BTN3A1 Antibody (CTX 2026)
SKU:
GXBS00880
Size:
100 µg, 1 mg
Antibody Type:
Monoclonal Antibody
Clone:
CTX 2026
Target:
BTF5
Isotype:
IgG1
Host Species:
Human
Reactivity:
Human
Applications:
ELISA, FCM, Functional assay, Research in vivo
Expression Host:
Mammalian cells
Synonyms:
CTX-2026
Recommended Dilutions:
ELISA: 1:2000-1:20000
Biological Activity:
CTX-2026 (1 ug/mL; 12 h) redirects the cytotoxic activity of Vγ9Vδ2 T cells from multiple donors against BTN3A1 + OVCAR3 cells or primary HGSOC cells [1]. CTX-2026 (1 ug/mL; 6 d) shows a rescuing effect on nonablated CD45 + T cells [1]. CTX-2026 (5 mg/kg; i.p. for 15 days every 3 days once) effects the tumor growth of NY-OVCAR3 tumor mice [1].
Purity:
>95% as determined by SDS-PAGE.
Endotoxin Level:
< 10 EU/mg
Formulation:
0.01M PBS pH 7.4.
State of Matter:
Liquid
Regulatory Status:
For research use only. Not suitable for clinical or therapeutic use.
Product Preparation:
Protein A/G purified from cell culture supernatant.
Storage and Handling:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
