Human CD326/EPCAM (ING-1) Antibody is a research-grade biosimilar monoclonal antibody. It is a human IgG1 antibody. Reactivity: Human. Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA, flow cytometry, functional assays and in vivo research. Endotoxin: < 10 EU/mg. Purity: >95% purity as determined by SDS-PAGE. For research use only.
Epithelial cell adhesion molecule (CD326/EPCAM) is a ~34 kDa protein. May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
Product Name:
Human CD326/EPCAM (ING-1) Antibody
SKU:
GXBS01281
Size:
100 µg, 1 mg
Antibody Type:
Monoclonal Antibody
Clone:
ING-1
Target:
Adenocarcinoma-associated antigen
Isotype:
IgG1
Host Species:
Human
Reactivity:
Human
Applications:
ELISA, FCM, Functional assay, Research in vivo
Synonyms:
ING-1, ING1, ING1
Biological Activity:
activity, targeting and inhibiting tumor growth and metastasis in mouse cancer models. ING-1 is useful in the research of breast, colorectal, and lung cancers, among other cancers [1] [2]. [1]. ING-1(37°C for 4 h) caused a concentration-dependent lysis of 51 Cr-labeled BT-20, MCF-7, HT-29, CACO-2, NCI-H1568, PC-3, HPAF-II cells in ADCC and CDC activity assay [1]. Parmacokinetics Species Dose Route V ss CL MRT T 1/2 T max C max Rat [1] 0.5 mg/kg i.v. 108 4.43 24.5 12.9 / / Rat [1] 5 mg/kg s.c. / 7.95 25.9 29.4 4.94 21.5 Rat [1] 50 mg/kg i.v. 114 4.56 25 5.85 / / ING-1 (0.1-1.0 mg/kg, i.v., two doses per week, 3 weeks) reduces tumor size and metastases in HT-29 and PC-3 xenograft nude mice model [1][2].
Purity:
>95% as determined by SDS-PAGE.
Endotoxin Level:
< 10 EU/mg
Formulation:
0.01M PBS pH 7.4.
State of Matter:
Liquid
Regulatory Status:
For research use only. Not suitable for clinical or therapeutic use.
Product Preparation:
Protein A/G purified from cell culture supernatant.
Storage and Handling:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
