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PE Anti-Human CD45 Antibody [HI30] (AGEL1678)

Datasheet MSDS
SKU AGEL1678
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Human
Host Species Mouse
Isotype IgG2a,k
Clone HI30
Conjugation PE
$37 - $162

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Description

system_update_altDatasheetsystem_update_altMSDS

PE Anti-Human CD45 Antibody [HI30]

The Human CD45 Monoclonal Antibody (PE Conjugated, HI30, AGEL1678) is a specialized tool for researchers studying human CD45, a key cell surface marker involved in immune cell activation and signaling. This monoclonal antibody, conjugated with PE for easy detection, is carefully manufactured for high reactivity and specificity when targeting CD45 in various experimental setups.CD45, also known as leukocyte common antigen, plays a crucial role in antigen recognition and signal transduction within the immune system. By targeting this protein, researchers can gain insights into immune cell functions, interaction dynamics, and disease mechanisms.

The PE conjugation enhances the antibody's visibility and utility in flow cytometry and fluorescence microscopy applications, facilitating detailed analysis of immune cell populations in complex biological samples.In the realm of immunology and cancer research, understanding the expression and regulation of CD45 is pivotal for elucidating immune responses, identifying immune cell subtypes, and investigating potential therapeutic targets. This PE-conjugated monoclonal antibody offers a precise tool for exploring CD45 biology, paving the way for advancements in immunotherapy, autoimmune disease research, and immune-related disorders.

Product Title:PE Anti-Human CD45 Antibody [HI30]
SKU:AGEL1678
Size:20 Tests, 100 Tests, 200 Tests
Clone No:HI30
Synonyms:Receptor-type tyrosine-protein phosphatase C;Ptprc;L-CA;Ly-5;T200;CD45;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:PE Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P08575
Gene ID:5788
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD45 is a 180 - 240 kD single chain type I membrane glycoprotein also known as leukocyte common antigen (LCA) and T200. It is a tyrosine phosphatase expressed on the plasma membrane of all hematopoietic cells, except erythrocytes or platelets. CD45 is a signaling molecule that regulates a variety of cellular processes including cell growth, differentiation, cell cycle, and oncogenic transformation. CD45 plays a critical role in T and B cell antigen receptor-mediated activation by dephosphorylating substrates including p56Lck, p59Fyn, and other Src family kinases. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to bind galectin-1 and to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4.
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