Human CD47/MER6 Antibody (CC-90002) is a research-grade biosimilar monoclonal antibody. It is a humanized IgG4 antibody. Reactivity: Human. Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA, flow cytometry, functional assays and in vivo research. Endotoxin: < 10 EU/mg. Purity: >95% purity as determined by SDS-PAGE. For research use only.
Leukocyte surface antigen CD47 (MER6) is a ~35 kDa protein. Adhesive protein that mediates cell-to-cell interactions. Acts as a receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins. Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation. Plays a role in modulating pulmonary endothelin EDN1 signaling. Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure. CD47 is the therapeutic target of magrolimab (clinical).
Product Name:
Human CD47/MER6 Antibody (CC-90002)
SKU:
GXBS00838
Size:
100 µg, 1 mg
Antibody Type:
Monoclonal Antibody
Clone:
CC-90002
Target:
Antigenic surface determinant protein OA3
Isotype:
IgG4
Host Species:
Human
Reactivity:
Human
Applications:
ELISA, FCM, Functional assay, Research in vivo
Synonyms:
CC-90002, INBRX-103, CC90002, DHG17620
Biological Activity:
CC-90002 has a high affinity for binding to CD47 with a subnanomolar dissociation constant (K d) value [1]. CC-90002 can block the CD47-SIRPa interaction with IC 50 value in the subnanomolar range [1]. CC-90002 has inhibitory effect in concentration-dependent in the ALL and AML cell lines [1]. CC-90002 shows significant dose-dependent antitumor activity and significant tumor regression in tumor xenografts models [1].
Purity:
>95% as determined by SDS-PAGE.
Endotoxin Level:
< 10 EU/mg
Formulation:
0.01M PBS pH 7.4.
State of Matter:
Liquid
Regulatory Status:
For research use only. Not suitable for clinical or therapeutic use.
Product Preparation:
Protein A/G purified from cell culture supernatant.
Storage and Handling:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
