Description

Purified Anti-Human CD62L Antibody [DREG56]

The Human CD62L Monoclonal Antibody (DREG56) is a specialized research tool offered by AssayGenie for the study of CD62L, a cell surface glycoprotein involved in leukocyte adhesion and migration. This monoclonal antibody, clone DREG56, is developed for reliable detection and analysis of CD62L in human samples, ensuring accurate results in various experimental settings. CD62L, also known as L-selectin, plays a crucial role in immune cell trafficking and homing to lymphoid tissues. Its expression is tightly regulated and serves as a key marker for leukocyte activation and migration. By targeting CD62L with the DREG56 antibody, researchers can investigate the mechanisms underlying immune cell recruitment and homing in conditions such as inflammation, infection, and cancer metastasis.

Validated for use in techniques like flow cytometry and immunohistochemistry, the Human CD62L Monoclonal Antibody (DREG56) from AssayGenie provides a valuable tool for studying the dynamics of immune cell interactions and migration. Researchers in immunology, oncology, and inflammatory disorders can benefit from its high specificity and sensitivity, enabling a deeper understanding of CD62L function in health and disease.

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Product Title:	Purified Anti-Human CD62L Antibody [DREG56]
SKU:	AGEL0222
Size:	25µg, 100µg
Clone No:	DREG56
Synonyms:	L-selectin;Sell;CD62 antigen-like family member L;LAM-1;LECAM1;Lymph node homing receptor;Ly-22; CD62L;Lnhr;Ly22;
Host Species:	Mouse
Reactivity:	Human
Application:	FCM

Isotype:	Mouse IgG1, κ
Isotype Control:	Purified Mouse IgG1, κ Isotype Control[MOPC-21]
Form:	Liquid
Conjugation:	Unconjugated
Recommended Use:	Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Swissprot:	P14151
Gene ID:	6402
Storage Buffer:	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Stability & Storage:	Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:	CD62L is a 74-95 kD single chain type I glycoprotein referred to as L-selectin or LECAM-1. It is expressed on most peripheral blood B cells, subsets of T and NK cells, monocytes, granulocytes, and certain hematopoietic malignant cells. CD62L binds to carbohydrates present on certain glycoforms of CD34, glycam-1, and MAdCAM-1 and with a low affinity to anionic oligosaccharide sequences related to sialylated Lewis X (sLex, CD15s) through its C-type lectin domain. CD62L is important for the homing of naïve lymphocytes to high endothelial venules in peripheral lymph nodes and Peyer's patches. It also plays a role in leukocyte rolling on activated endothelial cells.

Purified Anti-Human CD62L Antibody [DREG56] (AGEL0222)

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Description