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Human CD66a/CEACAM1 Antibody (MK-6018) - SDS-PAGE
Key Features

Human CD66a/CEACAM1 Antibody (MK-6018) (GXBS02139)

Datasheet MSDS
SKU GXBS02139
Product Type Research Grade Biosimilar
Antibody Type Monoclonal
Host Species Human
Reactivity Human
Applications ELISA, FCM, Functional assay, Research in vivo
Clone ID MK-6018
Isotype IgG4
€513 - €1,673

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Description

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Human CD66a/CEACAM1 Antibody (MK-6018)

Human CD66a/CEACAM1 Antibody (MK-6018) is a research-grade biosimilar monoclonal antibody targeting CD66. It is a human IgG4 antibody. Reactivity: Human. Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA, flow cytometry, functional assays and in vivo research. Endotoxin: < 10 EU/mg. Purity: >95% purity as determined by SDS-PAGE. For research use only.

Cell adhesion molecule CEACAM1 (CD66a) is a ~57 kDa protein. Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner. Plays a role as coinhibitory receptor in immune response, insulin action and also functions as an activator during angiogenesis. Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils. Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70.

Product Name:Human CD66a/CEACAM1 Antibody (MK-6018)
SKU:GXBS02139
Size:100 µg, 1 mg
Antibody Type:Monoclonal Antibody
Clone:MK-6018
Target:CD66a
Isotype:IgG4
Host Species:Human
Reactivity:Human
Applications:ELISA, FCM, Functional assay, Research in vivo
Expression Host:Mammalian cells
Synonyms:CD66a, BGP-1, Biliary glycoprotein 1, CEACAM1, Carcinoembryonic antigen-related cell adhesion molecule 1, BGP, BGP1
Purity:>95% as determined by SDS-PAGE.
Endotoxin Level:< 10 EU/mg
Formulation:0.01M PBS pH 7.4.
State of Matter:Liquid
Regulatory Status:For research use only. Not suitable for clinical or therapeutic use.
Product Preparation:Protein A/G purified from cell culture supernatant.
Storage and Handling:Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
UniProt:P13688
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