Description
Human CIB1 Recombinant Protein (N-His)
Human CIB1 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Gly2-Leu191, with an N-terminal His tag. Predicted molecular weight: 23.87 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Calcium and integrin-binding protein 1 (CIB1) is a ~21 kDa protein. Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. For research use only.
Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. 1. de Jong, SJ. et al. (2018) The Journal of experimental medicine 215, 2289-2310. PMID: 30068544 2. Wu, CJ. et al. (2020) The Journal of biological chemistry 295, 16086-16099. PMID: 32917726
| Product Name: | Human CIB1 Recombinant Protein (N-His) |
| SKU: | GXRP02784 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | CIBP, CIB1, Calcium- and integrin-binding protein, Calcium and integrin-binding protein 1, KIP, SIP2-28, DNA-PKcs-interacting protein, PRKDCIP, Calmyrin, CIB, Kinase-interacting protein, SNK-interacting protein 2-28 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Gly2-Leu191 |
| Calculated MW: | 23.87 kDa |
| UniProt: | Q99828 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
