Human CLDN1 Recombinant Protein (N-His) (GXRP00329)

Human CLDN1 Recombinant Protein (N-His)

Human CLDN1 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Met1-Val211, with an N-terminal His tag. Predicted molecular weight: 24.91 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Claudin-1 (CLDN1) is a ~22 kDa protein. Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. For research use only.

While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions.