Human CLOCK Recombinant Protein (N-His) (GXRP04885)

Human CLOCK Recombinant Protein (N-His)

Human CLOCK Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Ser106-Gly390, with an N-terminal His tag. Predicted molecular weight: 35.54 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Circadian locomoter output cycles protein kaput (CLOCK) is a ~95 kDa protein. Transcriptional activator which forms a core component of the circadian clock. For research use only.

The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers').